Na+/Ca2+ Exchanger Inhibitor

Na+/Ca2+ Exchanger Inhibitors (20):

Cat. No.	Product Name	Effect	Purity

HY-15754

CGP37157	Inhibitor	99.87%
CGP37157 is a potent, selective inhibitor of Na⁺/Ca²⁺ exchanger, inhibiting the Na⁺-induced Ca²⁺-release from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-101044

PPADS tetrasodium	Inhibitor
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺ exchanger in guinea pig airway smooth muscle.

HY-15415

KB-R7943 mesylate	Inhibitor	99.16%
KB-R7943 mesylate is a widely used inhibitor of the reverse Na⁺/Ca²⁺ exchanger (NCX_rev) with IC₅₀ of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.

HY-15515

SEA0400	Inhibitor	99.95%
SEA0400 is a novel and selective inhibitor of the Na⁺-Ca²⁺ exchanger (NCX), inhibiting Na⁺-dependent Ca²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-P10811

Na2+ - Ca2+ Exchanger inhibitory peptide	Inhibitor
Na⁺-Ca²⁺ Exchanger inhibitory peptide (XIP) is a Na⁺-Ca²⁺ exchanger inhibitor with a K_i of 200 nM. Na⁺-Ca²⁺ Exchanger inhibitory peptide inhibits the Na⁺-dependent Ca²⁺ uptake and the Na⁺-dependent Ca²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner.

HY-N15474

12-O-Deacetyl-phomoxanthone A	Inhibitor
12-O-Deacetyl-phomoxanthone A, a Na⁺/Ca²⁺ exchanger 1 (NCX1) activator, causes an increase in cellular Ca²⁺ signaling and subsequent inhibition of the downstream PI3K/AKT/β-catenin pathway. 12-O-Deacetyl-phomoxanthone A induces apoptosis and induces G1 phase arrest. 12-O-Deacetyl-phomoxanthone A can be used in the research for melanoma.

HY-B1546A

Benzamil hydrochloride	Inhibitor	99.70%
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na⁺/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-107658

SN 6	Inhibitor	99.79%
SN 6 is a selective Na⁺/Ca²⁺ exchanger (NCX) inhibitor, and inhibits ⁴⁵Ca²⁺ uptake by NCX1, NCX2, and NCX3, with IC₅₀s of 2.9, 16, and 8.6 μM, respectively.

HY-123785

ORM-10962	Inhibitor	99.49%
ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC₅₀ values of 67 and 55 nM for the reverse and forward mode inhibition, respectively. ORM-10962 shows antiarrhythmic effect.

HY-128678

ORM-10103	Inhibitor	99.43%
ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC₅₀s of 55 and 67 nM at -80 and at 20 mV, respectively.

HY-136182A

YM-244769	Inhibitor	99.22%
YM-244769 is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice.

HY-136182

YM-244769 dihydrochloride	Inhibitor	98.57%
YM-244769 dihydrochloride is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

HY-100298

Caldaret	Inhibitor	98.35%
Caldaret is an intracellular Ca²⁺ handling modulator that acts through reverse mode Na⁺/Ca²⁺ exchanger inhibition.

HY-107659

YM-244769 hydrochloride	Inhibitor	99.02%
YM-244769 hydrochloride is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

HY-138947

KB-R7943	Inhibitor
KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC₅₀ value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models.

HY-B1546

Benzamil	Inhibitor
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na⁺/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-164684

Dichlorobenzamil	Inhibitor
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits ⁴⁵Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC₅₀ = 18 μM). Dichlorobenzamil can also block K⁺ channels and voltage-sensitive Ca²⁺ channels.

HY-B1546AR

Benzamil hydrochloride (Standard)	Inhibitor
Benzamil (hydrochloride) (Standard) is the analytical standard of Benzamil (hydrochloride). This product is intended for research and analytical applications. Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.

HY-15515R

SEA0400 (Standard)	Inhibitor
SEA0400 (Standard) is the analytical standard of SEA0400. This product is intended for research and analytical applications. SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.

HY-19062

SM-6586	Inhibitor
SM-6586 is a calcium channel antagonist and inhibitor of Na⁺/H⁺ and Na⁺/Ca²⁺ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

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